HPV16 E7

Accession: H002764

Uniprot: S4S9D2

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE KLDLQPETT LYCYEHLND SEEEDEIDC AGQAEPDRA YKIVTFCCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLE LLMGILGIV P  

Epitope&Mutation

>H002764_E7
MHGDTPTLHEYKLDLQPETTDLYCYEHLNDSSEEEDEIDCPAGQAEPDRAHYKIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGILGIVCP
·HGDTPTLHEY(A1)·············································································
·················ETTDLYCYE(A1)······························································
···········································QAEPDRAHY(B18)···································
·························································CCKCDSTL(B8)·······················
·························································CCKCDSTLRLC(DR17)··················
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
······································································STHVDIRTLEDLLMG(DQB1*0201)
········································································HVDIRTLED(A2)·······