HPV16 E7

Accession: H002729

Uniprot: S4S8Y3

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLDLQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YIIVTFCCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLE LLMSTLGIV P  

Epitope&Mutation

>H002729_E7
MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYIIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMSTLGIVCP
MHGDTPTLHEYM(DR4 or DR15)···································································
MHGDTPTLHEYMLDL(A2)·········································································
·HGDTPTLHEY(A1)·············································································
····TPTLHEYMLDLQPE(MHC II)··································································
····TPTLHEYMLDLQPET(A2)·····································································
······TLHEYMLDL(A*0201)·····································································
······TLHEYMLDL(B48)········································································
······TLHEYMLDL(B8)·········································································
··········YMLDLQPET(A*0201)·································································
··········YMLDLQPETT(A*0201)································································
··········YMLDLQPETT(A*0201)································································
···········MLDLQPETT(A*0201)································································
···········MLDLQPETT(A2)····································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)··············································
·················ETTDLYCYE(A1)······························································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)·············································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
···········································QAEPDRAHY(B18)···································
·························································CCKCDSTL(B8)·······················
·························································CCKCDSTLRLC(DR17)··················
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
········································································HVDIRTLED(A2)·······