HPV16 E7

Accession: H002712

Uniprot: S4S8Y7

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE KLDLQPETT LYCDEQLNH SEGEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
CDSTPRLCVQ THVDIRTLE LLMGTLGIV P  

Epitope&Mutation

>H002712_E7
MHGDTPTLHEYKLDLQPETTDLYCDEQLNHSSEGEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTPRLCVQSTHVDIRTLEDLLMGTLGIVCP
·HGDTPTLHEY(A1)·············································································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
···········································QAEPDRAHY(B18)···································
···············································DRAHYNIVTFCCKCD(DR15)························
················································RAHYNIVTF(A*0201)···························
················································RAHYNIVTF(A24)······························
·················································AHYNIVTFCCKCD(DR15)························
··································································LCVQSTHVDI(A*2402)········
····································································VQSTHVDIRTLEDLLMGT(MHC II)
······································································STHVDIRTLEDLLMG(DQB1*0201)
········································································HVDIRTLED(A2)·······
···········································································IRTLEDLLMGT(DR12)
··············································································LEDLLMGTL(B60)
·················································································LLMGTLGIV(A*0201)