HPV16 E7

Accession: H002708

Uniprot: S4S9G8

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLDLQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
RDSTLRMCVQ THVDIRTLE LLMDTLGIV P  

Epitope&Mutation

>H002708_E7
MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKRDSTLRMCVQSTHVDIRTLEDLLMDTLGIVCP
MHGDTPTLHEYM(DR4 or DR15)···································································
MHGDTPTLHEYMLDL(A2)·········································································
·HGDTPTLHEY(A1)·············································································
····TPTLHEYMLDLQPE(MHC II)··································································
····TPTLHEYMLDLQPET(A2)·····································································
······TLHEYMLDL(A*0201)·····································································
······TLHEYMLDL(B48)········································································
······TLHEYMLDL(B8)·········································································
··········YMLDLQPET(A*0201)·································································
··········YMLDLQPETT(A*0201)································································
··········YMLDLQPETT(A*0201)································································
···········MLDLQPETT(A*0201)································································
···········MLDLQPETT(A2)····································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)··············································
·················ETTDLYCYE(A1)······························································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)·············································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
···········································QAEPDRAHY(B18)···································
················································RAHYNIVTF(A*0201)···························
················································RAHYNIVTF(A24)······························
········································································HVDIRTLED(A2)·······