HPV16 E7

Accession: H002589

Uniprot: S4S9E8

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MPGDIPTLHE KLDLQPETT LYCYEQLND SEEEDEIDG AGQAEQDRA YNIVTFCCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLE LFMGILGIV P  

Epitope&Mutation

>H002589_E7
MPGDIPTLHEYKLDLQPETTDLYCYEQLNDNSEEEDEIDGPAGQAEQDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLFMGILGIVCP
·················ETTDLYCYE(A1)······························································
···············································DRAHYNIVTFCCKCD(DR15)························
················································RAHYNIVTF(A*0201)···························
················································RAHYNIVTF(A24)······························
·················································AHYNIVTFCCKCD(DR15)························
··················································HYNIVTFCCKCDSTLRLCVQST(DP*1901)···········
·························································CCKCDSTL(B8)·······················
·························································CCKCDSTLRLC(DR17)··················
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
········································································HVDIRTLED(A2)·······