HPV16 E6
Accession: H002572
Uniprot: S4S8T1
Protein: E6
Organism: Human papillomavirus type 16
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . .
PPRKLPLLCT LQTTIHDII ECVYCEQKL RREVYEFAF DLCIVYKDG PYAVCDKCL
. . . . . .
KFYSKIIEYR YCYSVYGTT EQQYNKPLC LLIRCINCQ PLCPEEKQR LDKKQRFHN
. .
IRGRWTGRCM CCRSSRSRR TQL
Epitope&Mutation
Legend:mutationepitope
>H002572_E6
PPRKLPLLCTELQTTIHDIILECVYCEQKLLRREVYEFAFRDLCIVYKDGNPYAVCDKCLKFYSKIIEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRSRRETQL
··········ELQTTIHDIILECVY(A2)···················································································································
···········LQTTIHDII(A*0201)····················································································································
··············TIHDIILECV(A*0201)················································································································
··············TIHDIILEC(B*4801)·················································································································
················HDIILECV(B*4002)················································································································
·····································FAFRDLCIVY(B35)····························································································
·····································FAFRDLCIVY(B57)····························································································
·····································FAFRDLCIV(A*0201)··························································································
·····································FAFRDLCIV(A2)······························································································
···················································PYAVCDKCL(A*2402)············································································
·····················································AVCDKCLK(A11)··············································································
························································DKCLKFYS(A24)···········································································
······································································HYCYSVYGTTLEQQY(DR)·······················································
············································································YGTTLEQQYN(A24)·····················································
············································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·············································································GTTLEQQYNK(A11)····················································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··············································································TTLEQQYNK(A3)·····················································
··············································································TTLEQQYNK(A11)····················································
···················································································QYNKPLCDLL(A24)··············································
···················································································QYNKPLCDL(A*2402)············································
······················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·······················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
···························································································LLIRCINCQK(A11)······································
···························································································LLIRCINCQK(A3)·······································
···························································································LLIRCINCQK(A11)······································
··········································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
··········································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
··········································································································EKQRHLDKKQRFHNI(DR)···················
··············································································································HLDKKQRFH(A3)·····················
················································································································DKKQRFHNIRGRWTG(DRB1*01)········
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
······················································································································HNIRGRWTGR(A*6801)········
··························································································································GRWTGRCMSC(B27)·······
···························································································································RWTGRCMSCC(B27)······