HPV16 E7

Accession: H002564

Uniprot: S4S7U5

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE KLDLQPETT LCCYEQLND SEEEDEIDG TGQAEPDRA YTIVTFCCM
         .         .         .                              
CDSTLRLCVQ THVDIRTLE LLMGTLGIV P  

Epitope&Mutation

>H002564_E7
MHGDTPTLHEYKLDLQPETTDLCCYEQLNDSSEEEDEIDGPTGQAEPDRAHYTIVTFCCMCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCP
·HGDTPTLHEY(A1)·············································································
···········································QAEPDRAHY(B18)···································
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
····································································VQSTHVDIRTLEDLLMGT(MHC II)
······································································STHVDIRTLEDLLMG(DQB1*0201)
········································································HVDIRTLED(A2)·······
···········································································IRTLEDLLMGT(DR12)
··············································································LEDLLMGTL(B60)
·················································································LLMGTLGIV(A*0201)