HPV16 E7

Accession: H002534

Uniprot: S4S9E5

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MYGDTPTLHE MLDLQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YNIVIFCCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLE PLIGTLGIV P  

Epitope&Mutation

>H002534_E7
MYGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVIFCCKCDSTLRLCVQSTHVDIRTLEDPLIGTLGIVCP
····TPTLHEYMLDLQPE(MHC II)··································································
····TPTLHEYMLDLQPET(A2)·····································································
······TLHEYMLDL(A*0201)·····································································
······TLHEYMLDL(B48)········································································
······TLHEYMLDL(B8)·········································································
··········YMLDLQPET(A*0201)·································································
··········YMLDLQPETT(A*0201)································································
··········YMLDLQPETT(A*0201)································································
···········MLDLQPETT(A*0201)································································
···········MLDLQPETT(A2)····································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)··············································
·················ETTDLYCYE(A1)······························································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)·············································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
···········································QAEPDRAHY(B18)···································
·························································CCKCDSTL(B8)·······················
·························································CCKCDSTLRLC(DR17)··················
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
········································································HVDIRTLED(A2)·······