HPV16 E6

Accession: H002530

Uniprot: S4S8Y5

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLCT LQTTIHDIL ECVYCKQQL RREVYDFAF DLCIVYRDG PYAVCDKCI
         .         .         .         .         .         .
KFYSKISEYR YCYSVYGTT ELQYNKPLC LLFRCINCQ PLCPEEKQR LDNKQRFHN
         .         .                                        
IRGRWTGRCI CCRPSRTRR TQL   

Epitope&Mutation

>H002530_E6
PPRKLPQLCTELQTTIHDILLECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCIKFYSKISEYRRYCYSVYGTTLELQYNKPLCDLLFRCINCQKPLCPEEKQRHLDNKQRFHNIRGRWTGRCISCCRPSRTRRETQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
······················CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
··························KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
··································VYDFAFRDL(A*2402)·····························································································
·····································FAFRDLCIVY(B35)····························································································
·····································FAFRDLCIVY(B57)····························································································
·····································FAFRDLCIV(A*0201)··························································································
·····································FAFRDLCIV(A2)······························································································
············································IVYRDGNPY(A3)·······················································································
············································IVYRDGNPY(A11)······················································································
····························································KFYSKISEY(A24)······································································
····························································KFYSKISEY(B62)······································································
···················································································QYNKPLCDLL(A24)··············································
···················································································QYNKPLCDL(A*2402)············································
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
······················································································································HNIRGRWTGR(A*6801)········