HPV16 E6

Accession: H002529

Uniprot: S5THV5

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPG LPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYRDGNPY
         .         .         .         .         .         .
AVCDKCLKFY KISEYRHYC SLYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD
         .         .         .                              
KKQRFHNIRG WTGRCMSCC SSRTRRETQ   

Epitope&Mutation

>H002529_E6
MFQDPQERPGKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
··········KLPQLCTEL(A*0201)····························································································································
··········KLPQLCTEL(A2)································································································································
·················ELQTTIHDIILECVY(A2)···················································································································
··················LQTTIHDII(A*0201)····················································································································
·····················TIHDIILECV(A*0201)················································································································
·····················TIHDIILEC(B*4801)·················································································································
·······················HDIILECV(B*4002)················································································································
·························IILECVYCK(A11)················································································································
·····························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
·································KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
·········································VYDFAFRDL(A*2402)·····························································································
············································FAFRDLCIVY(B35)····························································································
············································FAFRDLCIVY(B57)····························································································
············································FAFRDLCIV(A*0201)··························································································
············································FAFRDLCIV(A2)······························································································
···············································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
···················································IVYRDGNPY(A3)·······················································································
···················································IVYRDGNPY(A11)······················································································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
··························································PYAVCDKCL(A*2402)············································································
····························································AVCDKCLK(A11)··············································································
·······························································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
·······························································DKCLKFYS(A24)···········································································
·································································CLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCD(DP)·················································
···································································KFYSKISEY(A24)······································································
···································································KFYSKISEY(B62)······································································
·····································································YSKISEYRHY(A1)····································································
········································································ISEYRHYCY(B18)·································································
········································································ISEYRHYCY(A1)··································································
········································································ISEYRHYCY(A11)·································································
··········································································EYRHYCYSL(A*2402)····························································
···············································································CYSLYGTTL(A*2402)·······················································
···············································································CYSLYGTTL(A24)··························································
···················································································YGTTLEQQYN(A24)·····················································
···················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
····················································································GTTLEQQYNK(A11)····················································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
·····················································································TTLEQQYNK(A3)·····················································
·····················································································TTLEQQYNK(A11)····················································
··························································································QYNKPLCDLL(A24)··············································
··························································································QYNKPLCDL(A*2402)············································
·····························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
··································································································LLIRCINCQK(A11)······································
··································································································LLIRCINCQK(A3)·······································
··································································································LLIRCINCQK(A11)······································
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
·················································································································EKQRHLDKKQRFHNI(DR)···················
·····················································································································HLDKKQRFH(A3)·····················
·······················································································································DKKQRFHNIRGRWTG(DRB1*01)········
·························································································································KQRFHNIRGR(DR*07)·············
···························································································································RFHNIRGRW(A24)··············
·····························································································································HNIRGRWTGR(A*6801)········
·································································································································GRWTGRCMSC(B27)·······
··································································································································RWTGRCMSCC(B27)······
············································································································································SSRTRRETQL(B14)