HPV16 E6

Accession: H002498

Uniprot: S5U276

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MHQKRTAMFQ PQERPRKLP LCTELQTTI DIILECVYC QQLLRRELY FAFRDLCIV
         .         .         .         .         .         .
YRDGNPYAVC KCLKFYSKI EYRHYCYSV GTTLEQQYN PLCDLLIRC NCQKPLCPE
         .         .         .                              
EKQRHLDKKQ FHNIRGRWT RCMSCCRSS TRRETQL  

Epitope&Mutation

>H002498_E6
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRRELYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
······AMFQDPQER(A3)···········································································································································
······AMFQDPQER(A11)··········································································································································
········FQDPQERPRK(A11)·······································································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*17)·······················································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*1401)·····················································································································
············QERPRKLPQL(B7)····································································································································
·················KLPQLCTEL(A*0201)····························································································································
·················KLPQLCTEL(A2)································································································································
························ELQTTIHDIILECVY(A2)···················································································································
·························LQTTIHDII(A*0201)····················································································································
····························TIHDIILECV(A*0201)················································································································
····························TIHDIILEC(B*4801)·················································································································
······························HDIILECV(B*4002)················································································································
································IILECVYCK(A11)················································································································
···················································FAFRDLCIVY(B35)····························································································
···················································FAFRDLCIVY(B57)····························································································
···················································FAFRDLCIV(A*0201)··························································································
···················································FAFRDLCIV(A2)······························································································
······················································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
··························································IVYRDGNPY(A3)·······················································································
··························································IVYRDGNPY(A11)······················································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·································································PYAVCDKCL(A*2402)············································································
···································································AVCDKCLK(A11)··············································································
······································································DKCLKFYS(A24)···········································································
··········································································KFYSKISEY(A24)······································································
··········································································KFYSKISEY(B62)······································································
············································································YSKISEYRHY(A1)····································································
···············································································ISEYRHYCY(B18)·································································
···············································································ISEYRHYCY(A1)··································································
···············································································ISEYRHYCY(A11)·································································
····················································································HYCYSVYGTTLEQQY(DR)·······················································
··························································································YGTTLEQQYN(A24)·····················································
··························································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
···························································································GTTLEQQYNK(A11)····················································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
····························································································TTLEQQYNK(A3)·····················································
····························································································TTLEQQYNK(A11)····················································
·································································································QYNKPLCDLL(A24)··············································
·································································································QYNKPLCDL(A*2402)············································
····································································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·····································································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
·········································································································LLIRCINCQK(A11)······································
·········································································································LLIRCINCQK(A3)·······································
·········································································································LLIRCINCQK(A11)······································
························································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
························································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
························································································································EKQRHLDKKQRFHNI(DR)···················
····························································································································HLDKKQRFH(A3)·····················
······························································································································DKKQRFHNIRGRWTG(DRB1*01)········
································································································································KQRFHNIRGR(DR*07)·············
··································································································································RFHNIRGRW(A24)··············
····································································································································HNIRGRWTGR(A*6801)········
········································································································································GRWTGRCMSC(B27)·······
·········································································································································RWTGRCMSCC(B27)······
···················································································································································SSRTRRETQL(B14)