HPV16 E6

Accession: H002480

Uniprot: S4S7W4

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLCT LQTTIHDIM ECVYCKQQL RREVYDFAF DFCIVYRDG PYAVCDKCI
         .         .         .         .         .         .
KFYSKISEYR YCYSVYGTT EQQYNKPLC LLIRCINCQ PLCPEEKQR LDNKQRFHN
         .         .                                        
IRGRWTCQCI CCRSSRTRR TQL   

Epitope&Mutation

>H002480_E6
PPRKLPQLCTELQTTIHDIMLECVYCKQQLLRREVYDFAFRDFCIVYRDGNPYAVCDKCIKFYSKISEYRRYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDNKQRFHNIRGRWTCQCISCCRSSRTRRETQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
············································IVYRDGNPY(A3)·······················································································
············································IVYRDGNPY(A11)······················································································
····························································KFYSKISEY(A24)······································································
····························································KFYSKISEY(B62)······································································
············································································YGTTLEQQYN(A24)·····················································
············································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·············································································GTTLEQQYNK(A11)····················································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··············································································TTLEQQYNK(A3)·····················································
··············································································TTLEQQYNK(A11)····················································
···················································································QYNKPLCDLL(A24)··············································
···················································································QYNKPLCDL(A*2402)············································
······················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·······················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
···························································································LLIRCINCQK(A11)······································
···························································································LLIRCINCQK(A3)·······································
···························································································LLIRCINCQK(A11)······································
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
·····································································································································SSRTRRETQL(B14)