HPV68 E6

Accession: H002465

Uniprot: T2A7H5

Protein: E6

Organism: Human papillomavirus type 68

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MALFHNPEER YKLPDLCRT DTTLHDVAI CVYCRRQLQ TEVYEFAFS LYVVYRDGV
         .         .         .         .         .         .
PFAACQSCIK YAKIRELRY SESVYATTL TITNTKLYN LIRCMSCLK LCPAEKLRH
         .         .         .                              
LTTKRRLHKI GNFTGQCRH WTSKREDRR IRQETQV