HPV16 E6

Accession: H002459

Uniprot: S5TGH2

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPR LPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYKDGNPY
         .         .         .         .         .         .
AVCDKCLKFY KISEYRHYC SVYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD
         .         .         .                              
KKQRFHNIRG WTGRCMSCC SSRTRRETQ   

Epitope&Mutation

>H002459_E6
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYKDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
·FQDPQERPRK(A11)·······································································································································
···DPQERPRKLPQLCTELQTTIHD(DP*17)·······················································································································
···DPQERPRKLPQLCTELQTTIHD(DP*1401)·····················································································································
·····QERPRKLPQL(B7)····································································································································
··········KLPQLCTEL(A*0201)····························································································································
··········KLPQLCTEL(A2)································································································································
·················ELQTTIHDIILECVY(A2)···················································································································
··················LQTTIHDII(A*0201)····················································································································
·····················TIHDIILECV(A*0201)················································································································
·····················TIHDIILEC(B*4801)·················································································································
·······················HDIILECV(B*4002)················································································································
·························IILECVYCK(A11)················································································································
·········································VYDFAFRDL(A*2402)·····························································································
············································FAFRDLCIVY(B35)····························································································
············································FAFRDLCIVY(B57)····························································································
············································FAFRDLCIV(A*0201)··························································································
············································FAFRDLCIV(A2)······························································································
··························································PYAVCDKCL(A*2402)············································································
····························································AVCDKCLK(A11)··············································································
·······························································DKCLKFYS(A24)···········································································
···································································KFYSKISEY(A24)······································································
···································································KFYSKISEY(B62)······································································
·····································································YSKISEYRHY(A1)····································································
········································································ISEYRHYCY(B18)·································································
········································································ISEYRHYCY(A1)··································································
········································································ISEYRHYCY(A11)·································································
·············································································HYCYSVYGTTLEQQY(DR)·······················································
···················································································YGTTLEQQYN(A24)·····················································
···················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
····················································································GTTLEQQYNK(A11)····················································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
·····················································································TTLEQQYNK(A3)·····················································
·····················································································TTLEQQYNK(A11)····················································
··························································································QYNKPLCDLL(A24)··············································
··························································································QYNKPLCDL(A*2402)············································
·····························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
··································································································LLIRCINCQK(A11)······································
··································································································LLIRCINCQK(A3)·······································
··································································································LLIRCINCQK(A11)······································
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
·················································································································EKQRHLDKKQRFHNI(DR)···················
·····················································································································HLDKKQRFH(A3)·····················
·······················································································································DKKQRFHNIRGRWTG(DRB1*01)········
·························································································································KQRFHNIRGR(DR*07)·············
···························································································································RFHNIRGRW(A24)··············
·····························································································································HNIRGRWTGR(A*6801)········
·································································································································GRWTGRCMSC(B27)·······
··································································································································RWTGRCMSCC(B27)······
············································································································································SSRTRRETQL(B14)