HPV16 E6

Accession: H002445

Uniprot: S4S9F0

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLCT LQTIIHDII ECVYCKQQL RREVYDFAF DLCIVYRDG PYAVCDKCL
         .         .         .         .         .         .
KFYSKIIEYR YCYSVYGTT EQQYNKPLC LLIRCINCQ PLCPEEKQR LDKKQRFHN
         .         .                                        
IRGRWSGRCM CCRSSRTRR TQL   

Epitope&Mutation

>H002445_E6
PPRKLPQLCTELQTIIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKIIEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWSGRCMSCCRSSRTRRETQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
················HDIILECV(B*4002)················································································································
··················IILECVYCK(A11)················································································································
······················CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
··························KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
··································VYDFAFRDL(A*2402)·····························································································
·····································FAFRDLCIVY(B35)····························································································
·····································FAFRDLCIVY(B57)····························································································
·····································FAFRDLCIV(A*0201)··························································································
·····································FAFRDLCIV(A2)······························································································
············································IVYRDGNPY(A3)·······················································································
············································IVYRDGNPY(A11)······················································································
···················································PYAVCDKCL(A*2402)············································································
·····················································AVCDKCLK(A11)··············································································
························································DKCLKFYS(A24)···········································································
······································································HYCYSVYGTTLEQQY(DR)·······················································
············································································YGTTLEQQYN(A24)·····················································
············································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·············································································GTTLEQQYNK(A11)····················································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··············································································TTLEQQYNK(A3)·····················································
··············································································TTLEQQYNK(A11)····················································
···················································································QYNKPLCDLL(A24)··············································
···················································································QYNKPLCDL(A*2402)············································
······················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·······················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
···························································································LLIRCINCQK(A11)······································
···························································································LLIRCINCQK(A3)·······································
···························································································LLIRCINCQK(A11)······································
··········································································································EKQRHLDKKQRFHNI(DR)···················
··············································································································HLDKKQRFH(A3)·····················
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
·····································································································································SSRTRRETQL(B14)