HPV16 E6

Accession: H002401

Uniprot: S4S7W8

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLCT LQTTIHDII ECVYCMQQL RREVYDFAF DSCIVYRDG PFAVCGKCL
         .         .         .         .         .         .
KFYSKVSEYR YCYSVYGTT EQQYNKPLC LLIRCINRQ PLCPEEKQR LDKKQRFHN
         .         .                                        
IRGWWTGRCM FCRSSRTHR TQL   

Epitope&Mutation

>H002401_E6
PPRKLPQLCTELQTTIHDIILECVYCMQQLLRREVYDFAFRDSCIVYRDGNPFAVCGKCLKFYSKVSEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINRQKPLCPEEKQRHLDKKQRFHNIRGWWTGRCMSFCRSSRTHRETQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
··········ELQTTIHDIILECVY(A2)···················································································································
···········LQTTIHDII(A*0201)····················································································································
··············TIHDIILECV(A*0201)················································································································
··············TIHDIILEC(B*4801)·················································································································
················HDIILECV(B*4002)················································································································
······································································HYCYSVYGTTLEQQY(DR)·······················································
············································································YGTTLEQQYN(A24)·····················································
············································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·············································································GTTLEQQYNK(A11)····················································
··············································································TTLEQQYNK(A3)·····················································
··············································································TTLEQQYNK(A11)····················································
···················································································QYNKPLCDLL(A24)··············································
···················································································QYNKPLCDL(A*2402)············································
··········································································································EKQRHLDKKQRFHNI(DR)···················
··············································································································HLDKKQRFH(A3)·····················