HPV18 E5

Accession: H002377

Uniprot: T2A669

Protein: E5

Organism: Human papillomavirus type 18

Function

It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu

Sequence&Mutation

         .         .         .         .         .         .
MLPLIFLFCV VCLYVCCHV LLPSVCMCA AWVLVFVYI VITSPATAF VYVFCFLLP
         .                                                  
MLLLHIHAIL LQ