HPV16 E7

Accession: H002360

Uniprot: S4S9F8

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MYGDTPTLHE MLDLQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLD LLMGTLGIV P  

Epitope&Mutation

>H002360_E7
MYGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLDALLMGTLGIVCP
····TPTLHEYMLDLQPE(MHC II)··································································
····TPTLHEYMLDLQPET(A2)·····································································
······TLHEYMLDL(A*0201)·····································································
······TLHEYMLDL(B48)········································································
······TLHEYMLDL(B8)·········································································
··········YMLDLQPET(A*0201)·································································
··········YMLDLQPETT(A*0201)································································
··········YMLDLQPETT(A*0201)································································
···········MLDLQPETT(A*0201)································································
···········MLDLQPETT(A2)····································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)··············································
·················ETTDLYCYE(A1)······························································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)·············································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
··········································GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIR(DR3)··········
··········································GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDI(DR3)···········
···········································QAEPDRAHY(B18)···································
···············································DRAHYNIVTFCCKCD(DR15)························
················································RAHYNIVTF(A*0201)···························
················································RAHYNIVTF(A24)······························
·················································AHYNIVTFCCKCD(DR15)························
··················································HYNIVTFCCKCDSTLRLCVQST(DP*1901)···········
·························································CCKCDSTL(B8)·······················
·························································CCKCDSTLRLC(DR17)··················
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
·················································································LLMGTLGIV(A*0201)