HPV16 E6

Accession: H002349

Uniprot: S5THF4

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPG LPDLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYRDGNPY
         .         .         .         .         .         .
AVCEKCLKFY KISEYRYYC SVYGTTLEQ YNKPLCNLL RCINCQKPL PEEKQRHLD
         .         .         .                              
KKQRFHNIRG WTGRCMSCC SSRTRRETQ   

Epitope&Mutation

>H002349_E6
MFQDPQERPGKLPDLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCEKCLKFYSKISEYRYYCYSVYGTTLEQQYNKPLCNLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
··········KLPDLCTEL(A*0201)····························································································································
·················ELQTTIHDIILECVY(A2)···················································································································
··················LQTTIHDII(A*0201)····················································································································
·····················TIHDIILECV(A*0201)················································································································
·····················TIHDIILEC(B*4801)·················································································································
·······················HDIILECV(B*4002)················································································································
·························IILECVYCK(A11)················································································································
·····························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
·································KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
·········································VYDFAFRDL(A*2402)·····························································································
············································FAFRDLCIVY(B35)····························································································
············································FAFRDLCIVY(B57)····························································································
············································FAFRDLCIV(A*0201)··························································································
············································FAFRDLCIV(A2)······························································································
···················································IVYRDGNPY(A3)·······················································································
···················································IVYRDGNPY(A11)······················································································
···································································KFYSKISEY(A24)······································································
···································································KFYSKISEY(B62)······································································
···················································································YGTTLEQQYN(A24)·····················································
····················································································GTTLEQQYNK(A11)····················································
·····················································································TTLEQQYNK(A3)·····················································
·····················································································TTLEQQYNK(A11)····················································
··································································································LLIRCINCQK(A11)······································
··································································································LLIRCINCQK(A3)·······································
··································································································LLIRCINCQK(A11)······································
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
·················································································································EKQRHLDKKQRFHNI(DR)···················
·····················································································································HLDKKQRFH(A3)·····················
·······················································································································DKKQRFHNIRGRWTG(DRB1*01)········
·························································································································KQRFHNIRGR(DR*07)·············
···························································································································RFHNIRGRW(A24)··············
·····························································································································HNIRGRWTGR(A*6801)········
·································································································································GRWTGRCMSC(B27)·······
··································································································································RWTGRCMSCC(B27)······
············································································································································SSRTRRETQL(B14)