HPV16 E7

Accession: H002335

Uniprot: S4S9G4

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLDLQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
CDSTLRLCLQ THVDIRTLE LLMGTLGIV P  

Epitope&Mutation

>H002335_E7
MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCLQSTHVDIRTLEDLLMGTLGIVCP
MHGDTPTLHEYM(DR4 or DR15)···································································
MHGDTPTLHEYMLDL(A2)·········································································
·HGDTPTLHEY(A1)·············································································
····TPTLHEYMLDLQPE(MHC II)··································································
····TPTLHEYMLDLQPET(A2)·····································································
······TLHEYMLDL(A*0201)·····································································
······TLHEYMLDL(B48)········································································
······TLHEYMLDL(B8)·········································································
··········YMLDLQPET(A*0201)·································································
··········YMLDLQPETT(A*0201)································································
··········YMLDLQPETT(A*0201)································································
···········MLDLQPETT(A*0201)································································
···········MLDLQPETT(A2)····································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)··············································
·················ETTDLYCYE(A1)······························································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)·············································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
···········································QAEPDRAHY(B18)···································
···············································DRAHYNIVTFCCKCD(DR15)························
················································RAHYNIVTF(A*0201)···························
················································RAHYNIVTF(A24)······························
·················································AHYNIVTFCCKCD(DR15)························
·························································CCKCDSTL(B8)·······················
·························································CCKCDSTLRLC(DR17)··················
······································································STHVDIRTLEDLLMG(DQB1*0201)
········································································HVDIRTLED(A2)·······
···········································································IRTLEDLLMGT(DR12)
··············································································LEDLLMGTL(B60)
·················································································LLMGTLGIV(A*0201)