HPV16 E6

Accession: H002334

Uniprot: S4S897

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLYT LQTTIHDII ECVYCKQQL RREVYDFAF DLCIVYRDG PYAVCDKCL
         .         .         .         .         .         .
KFYSKISEYR YCYSVYGTT EQQYNKPLC MLIRCINCQ PLCPEEKQR LEKKQRFHN
         .         .                                        
IRGRWTGRSM CCRSSRTRR TQL   

Epitope&Mutation

>H002334_E6
PPRKLPQLYTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDMLIRCINCQKPLCPEEKQRHLEKKQRFHNIRGRWTGRSMSCCRSSRTRRETQL
··········ELQTTIHDIILECVY(A2)···················································································································
···········LQTTIHDII(A*0201)····················································································································
··············TIHDIILECV(A*0201)················································································································
··············TIHDIILEC(B*4801)·················································································································
················HDIILECV(B*4002)················································································································
··················IILECVYCK(A11)················································································································
······················CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
··························KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
··································VYDFAFRDL(A*2402)·····························································································
·····································FAFRDLCIVY(B35)····························································································
·····································FAFRDLCIVY(B57)····························································································
·····································FAFRDLCIV(A*0201)··························································································
·····································FAFRDLCIV(A2)······························································································
········································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
············································IVYRDGNPY(A3)·······················································································
············································IVYRDGNPY(A11)······················································································
··············································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
··············································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
···················································PYAVCDKCL(A*2402)············································································
·····················································AVCDKCLK(A11)··············································································
························································DKCLKFYS(A24)···········································································
····························································KFYSKISEY(A24)······································································
····························································KFYSKISEY(B62)······································································
······························································YSKISEYRHY(A1)····································································
·································································ISEYRHYCY(B18)·································································
·································································ISEYRHYCY(A1)··································································
·································································ISEYRHYCY(A11)·································································
······································································HYCYSVYGTTLEQQY(DR)·······················································
············································································YGTTLEQQYN(A24)·····················································
·············································································GTTLEQQYNK(A11)····················································
··············································································TTLEQQYNK(A3)·····················································
··············································································TTLEQQYNK(A11)····················································
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
······················································································································HNIRGRWTGR(A*6801)········
·····································································································································SSRTRRETQL(B14)