HPV16 E6

Accession: H002303

Uniprot: S4S8M7

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLCT LQTTIHDII ECVYCKQQL RREVYDFAF DLCIVYRDG PYNVCDKCL
         .         .         .         .         .         .
KFYSKISEYR YYYSVYGTT EQQYNKPLC LLIRCINCQ PLCPEEKQR LDKKQRFHN
         .         .                                        
IRGRWTGRCM CCRSSRTRR TQL   

Epitope&Mutation

>H002303_E6
PPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYNVCDKCLKFYSKISEYRQYYYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRYLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
··········ELQTTIHDIILECVY(A2)···················································································································
···········LQTTIHDII(A*0201)····················································································································
··············TIHDIILECV(A*0201)················································································································
··············TIHDIILEC(B*4801)·················································································································
················HDIILECV(B*4002)················································································································
··················IILECVYCK(A11)················································································································
··························KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
··································VYDFAFRDL(A*2402)·····························································································
·····································FAFRDLCIVY(B35)····························································································
·····································FAFRDLCIVY(B57)····························································································
·····································FAFRDLCIV(A*0201)··························································································
·····································FAFRDLCIV(A2)······························································································
············································IVYRDGNPY(A3)·······················································································
············································IVYRDGNPY(A11)······················································································
························································DKCLKFYS(A24)···········································································
····························································KFYSKISEY(A24)······································································
····························································KFYSKISEY(B62)······································································
············································································YGTTLEQQYN(A24)·····················································
············································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·············································································GTTLEQQYNK(A11)····················································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··············································································TTLEQQYNK(A3)·····················································
··············································································TTLEQQYNK(A11)····················································
···················································································QYNKPLCDLL(A24)··············································
···················································································QYNKPLCDL(A*2402)············································
······················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·······················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
···························································································LLIRCINCQK(A11)······································
···························································································LLIRCINCQK(A3)·······································
···························································································LLIRCINCQK(A11)······································
················································································································DKKQRFHNIRGRWTG(DRB1*01)········
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
······················································································································HNIRGRWTGR(A*6801)········
··························································································································GRWTGRCMSC(B27)·······
···························································································································RWTGRCMSCC(B27)······
·····································································································································SSRTRRETQL(B14)