HPV16 E6

Accession: H002302

Uniprot: S4S8U6

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLCT LQTTIHDIV ECVYCKQQI RREVYDFAF DLCIVNRDG PYAVCDKCL
         .         .         .         .         .         .
KFYSKISEYR YCYSLYGTT EHQYNKPLC LLIRCINCQ PLCPEEKQR LDKKQRFHN
         .         .                                        
IRGRWTGRCM CCRSSRTRR TQL   

Epitope&Mutation

>H002302_E6
PPRKLPQLCTELQTTIHDIVLECVYCKQQILRREVYDFAFRDLCIVNRDGNPYAVCDKCLKFYSKISEYRQYCYSLYGTTLEHQYNKPLCELLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
··································VYDFAFRDL(A*2402)·····························································································
·····································FAFRDLCIV(A*0201)··························································································
·····································FAFRDLCIV(A2)······························································································
···················································PYAVCDKCL(A*2402)············································································
·····················································AVCDKCLK(A11)··············································································
························································DKCLKFYS(A24)···········································································
····························································KFYSKISEY(A24)······································································
····························································KFYSKISEY(B62)······································································
········································································CYSLYGTTL(A*2402)·······················································
········································································CYSLYGTTL(A24)··························································
···························································································LLIRCINCQK(A11)······································
···························································································LLIRCINCQK(A3)·······································
···························································································LLIRCINCQK(A11)······································
··········································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
··········································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
··········································································································EKQRHLDKKQRFHNI(DR)···················
··············································································································HLDKKQRFH(A3)·····················
················································································································DKKQRFHNIRGRWTG(DRB1*01)········
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
······················································································································HNIRGRWTGR(A*6801)········
··························································································································GRWTGRCMSC(B27)·······
···························································································································RWTGRCMSCC(B27)······
·····································································································································SSRTRRETQL(B14)