HPV16 E6
Accession: H002289
Uniprot: S4S8B7
Protein: E6
Organism: Human papillomavirus type 16
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . .
PPRKLPQLCT LQTTIHDII ECVYCKQRL RREVYDFVF DLCIVYRDG PYAVCDKCL
. . . . . .
KFYSKISEYR YCYSLYGTT EQQYNNPLC LLIRCINCQ PLCPEEKQR LDKKQRFHN
. .
IRGRWTGRCM CCRSSRICR TQL
Epitope&Mutation
Legend:mutationepitope
>H002289_E6
PPRKLPQLCTELQTTIHDIILECVYCKQRLLRREVYDFVFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNNPLCDLLIRCINCQRPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRICRETQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
··········ELQTTIHDIILECVY(A2)···················································································································
···········LQTTIHDII(A*0201)····················································································································
··············TIHDIILECV(A*0201)················································································································
··············TIHDIILEC(B*4801)·················································································································
················HDIILECV(B*4002)················································································································
··················IILECVYCK(A11)················································································································
········································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
············································IVYRDGNPY(A3)·······················································································
············································IVYRDGNPY(A11)······················································································
··············································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
··············································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
···················································PYAVCDKCL(A*2402)············································································
·····················································AVCDKCLK(A11)··············································································
························································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
························································DKCLKFYS(A24)···········································································
····························································KFYSKISEY(A24)······································································
····························································KFYSKISEY(B62)······································································
······························································YSKISEYRHY(A1)····································································
·································································ISEYRHYCY(B18)·································································
·································································ISEYRHYCY(A1)··································································
·································································ISEYRHYCY(A11)·································································
···································································EYRHYCYSL(A*2402)····························································
········································································CYSLYGTTL(A*2402)·······················································
········································································CYSLYGTTL(A24)··························································
············································································YGTTLEQQYN(A24)·····················································
··········································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
··········································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
··········································································································EKQRHLDKKQRFHNI(DR)···················
··············································································································HLDKKQRFH(A3)·····················
················································································································DKKQRFHNIRGRWTG(DRB1*01)········
··················································································································KQRFHNIRGR(DR*07)·············
····················································································································RFHNIRGRW(A24)··············
······················································································································HNIRGRWTGR(A*6801)········
··························································································································GRWTGRCMSC(B27)·······
···························································································································RWTGRCMSCC(B27)······