HPV16 E7

Accession: H002275

Uniprot: S4S8Q3

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLVLQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLE LLMGTLGIV P  

Epitope&Mutation

>H002275_E7
MHGDTPTLHEYMLVLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEGLLMGTLGIVCP
MHGDTPTLHEYM(DR4 or DR15)···································································
·HGDTPTLHEY(A1)·············································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)··············································
·················ETTDLYCYE(A1)······························································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)·············································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
··········································GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIR(DR3)··········
··········································GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDI(DR3)···········
···········································QAEPDRAHY(B18)···································
···············································DRAHYNIVTFCCKCD(DR15)························
················································RAHYNIVTF(A*0201)···························
················································RAHYNIVTF(A24)······························
·················································AHYNIVTFCCKCD(DR15)························
··················································HYNIVTFCCKCDSTLRLCVQST(DP*1901)···········
·························································CCKCDSTL(B8)·······················
·························································CCKCDSTLRLC(DR17)··················
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
·················································································LLMGTLGIV(A*0201)