HPV18 E6

Accession: H002239

Uniprot: R9VZD6

Protein: E6

Organism: Human papillomavirus type 18

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .                                                  
MARFEDPTRR YKLPDR