HPV16 E6

Accession: H002218

Uniprot: S4S8U2

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PPRKLPQLCT LQTTIYDII ECVYCKQHL RREIYDFAF DLCIVYRHG PFAVCDKCL
         .         .         .         .         .         .
KFYSKISEYR YCYSLYGTT EQQYNKPLC LLIRCINCQ PLCPEEKQR LDKKQRFHN
         .         .                                        
IRGQWTGRCM CCRSSRTCR TQL   

Epitope&Mutation

>H002218_E6
PPRKLPQLCTELQTTIYDIILECVYCKQHLLRREIYDFAFRDLCIVYRHGNPFAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGQWTGRCMSCCRSSRTCRDTQL
···KLPQLCTEL(A*0201)····························································································································
···KLPQLCTEL(A2)································································································································
··················IILECVYCK(A11)················································································································
·····································FAFRDLCIVY(B35)····························································································
·····································FAFRDLCIVY(B57)····························································································
·····································FAFRDLCIV(A*0201)··························································································
·····································FAFRDLCIV(A2)······························································································
·····················································AVCDKCLK(A11)··············································································
························································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
························································DKCLKFYS(A24)···········································································
··························································CLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCD(DP)·················································
····························································KFYSKISEY(A24)······································································
····························································KFYSKISEY(B62)······································································
······························································YSKISEYRHY(A1)····································································
·································································ISEYRHYCY(B18)·································································
·································································ISEYRHYCY(A1)··································································
·································································ISEYRHYCY(A11)·································································
···································································EYRHYCYSL(A*2402)····························································
········································································CYSLYGTTL(A*2402)·······················································
········································································CYSLYGTTL(A24)··························································
············································································YGTTLEQQYN(A24)·····················································
············································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·············································································GTTLEQQYNK(A11)····················································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··············································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··············································································TTLEQQYNK(A3)·····················································
··············································································TTLEQQYNK(A11)····················································
···················································································QYNKPLCDLL(A24)··············································
···················································································QYNKPLCDL(A*2402)············································
······················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·······················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
···························································································LLIRCINCQK(A11)······································
···························································································LLIRCINCQK(A3)·······································
···························································································LLIRCINCQK(A11)······································
··········································································································EKQRHLDKKQRFHNI(DR)···················
··············································································································HLDKKQRFH(A3)·····················