HPV59 E6

Accession: H002216

Uniprot: T2A6S8

Protein: E6

Organism: Human papillomavirus type 59

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

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MARFEDPTQR YKLPDLSTT NIPLHDIRI CVFCKGELQ REVFEFAFN LFIVYRDCT
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PYAACLKCIS YARVRELRY RDSVYGETL AETKTPLHE LIRCYRCLK LCPTDKLKH
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ITEKRRFHNI GVYTGQCRG RTRARHLRQ RQARSETLV