HPV16 E2

Accession: H002198

Uniprot: S4W1C8

Protein: E2

Organism: Human papillomavirus type 16

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Sequence&Mutation

         .         .         .         .         .         .
METLCQRLNV QDKILTHYE DSTNLRDHI YWKHMRLEC IYYKAREMG KHINHQVVP
         .         .         .         .         .         .
TLAVSKNKAL AIELQLTLE IYNSQYSNE WTLQDVSLE YLTAPTGCI KHGYTVEVQ
         .         .         .         .         .         .
FDGDICNTMH TNWKHIYIC EASVTVVEG VDYYGLYYV EGIQTYFVQ KEDAEKYSK
         .         .         .         .         .         .
NKVWEVHAGG VILCPTSVF SNEVSSPET RQHLANHSA THTKAVALG KETQTTIQR
         .         .         .         .         .         .
PRSEPDTGNP HTTKLLHRD VDSAPILTA NSSHKGRIN NSNTTPIVH KGDANTLKC
         .         .         .         .         .         .
LRYRFKKHCK YTAVSSTWH TGHNVKHKS IVTLTYDSE QREQFLSQV IPKTITVST
                                                            
GFMSI     

Epitope&Mutation

>H002198_E2
METLCQRLNVCQDKILTHYENDSTNLRDHIDYWKHMRLECAIYYKAREMGFKHINHQVVPTLAVSKNKALQAIELQLTLETIYNSQYSNEKWTLQDVSLEVYLTAPTGCIKKHGYTVEVQFDGDICNTMHYTNWKHIYICEEASVTVVEGQVDYYGLYYVHEGIQTYFVQFKEDAEKYSKNKVWEVHAGGQVILCPTSVFSSNEVSSPETIRQHLANHSAATHTKAVALGTKETQTTIQRPRSEPDTGNPCHTTKLLHRDSVDSAPILTAFNSSHKGRINCNSNTTPIVHLKGDANTLKCLRYRFKKHCKLYTAVSSTWHWTGHNVKHKSAIVTLTYDSEWQREQFLSQVKIPKTITVSTGFMSI
····································································ALQAIELQL(A*0201)························································································································································································································································································
····························································································TLQDVSLEV(A*0201)································································································································································································································································
·········································································································································YICEEASVTV(A*0201)··················································································································································································································
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··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR1)····························································
··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR2)····························································
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·····························································································································································································································································································································································KIPKTITVSTGFMSI(DR1)