HPV16 E5

Accession: H002125

Uniprot: Q9WIV8

Protein: E5

Organism: Human papillomavirus type 16

Function

It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu

Sequence&Mutation

         .         .         .         .         .         .
ASTTLLACFL CFCVLLCVC LIRPLLLSV TYTLLILLV LLWITAASA RCFIVYIVF
                                                            
VYIPLFLIHT     

Epitope&Mutation

>H002125_E5
ASTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYTLLILLVLLLWITAASAFRCFIVYIVFVYIPLFLIHT
········FLLCFCVLL(A*0201)·············································
··············VLLCVCLLI(A*0201)·······································
·······································VLLLWITAA(A*0201)··············