HPV16 E6

Accession: H002102

Uniprot: K0FAI3

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
DPQERPRTLP LCTELQTTI EIILECVYC QQLLRREVY FAFRDLCIV RDGNPYAVC
         .         .         .         .         .         .
DKCLKFYSKI EYRHYCYSL GTTLEQQYN PLCDLLIRC NCQKPLCPE KQRHLDKKQ
         .         .                                        
RFHNIRGRWT RCMSCCRSS TRRETQL   

Epitope&Mutation

>H002102_E6
DPQERPRTLPQLCTELQTTIHEIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
······················IILECVYCK(A11)················································································································
··························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
······························KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
······································VYDFAFRDL(A*2402)·····························································································
·········································FAFRDLCIVY(B35)····························································································
·········································FAFRDLCIVY(B57)····························································································
·········································FAFRDLCIV(A*0201)··························································································
·········································FAFRDLCIV(A2)······························································································
············································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
················································IVYRDGNPY(A3)·······················································································
················································IVYRDGNPY(A11)······················································································
··················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
··················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·······················································PYAVCDKCL(A*2402)············································································
·························································AVCDKCLK(A11)··············································································
····························································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
····························································DKCLKFYS(A24)···········································································
······························································CLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCD(DP)·················································
································································KFYSKISEY(A24)······································································
································································KFYSKISEY(B62)······································································
··································································YSKISEYRHY(A1)····································································
·····································································ISEYRHYCY(B18)·································································
·····································································ISEYRHYCY(A1)··································································
·····································································ISEYRHYCY(A11)·································································
·······································································EYRHYCYSL(A*2402)····························································
············································································CYSLYGTTL(A*2402)·······················································
············································································CYSLYGTTL(A24)··························································
················································································YGTTLEQQYN(A24)·····················································
················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·················································································GTTLEQQYNK(A11)····················································
··················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··················································································TTLEQQYNK(A3)·····················································
··················································································TTLEQQYNK(A11)····················································
·······················································································QYNKPLCDLL(A24)··············································
·······················································································QYNKPLCDL(A*2402)············································
··························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
···························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
·······························································································LLIRCINCQK(A11)······································
·······························································································LLIRCINCQK(A3)·······································
·······························································································LLIRCINCQK(A11)······································
··············································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
··············································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
··············································································································EKQRHLDKKQRFHNI(DR)···················
··················································································································HLDKKQRFH(A3)·····················
····················································································································DKKQRFHNIRGRWTG(DRB1*01)········
······················································································································KQRFHNIRGR(DR*07)·············
························································································································RFHNIRGRW(A24)··············
··························································································································HNIRGRWTGR(A*6801)········
······························································································································GRWTGRCMSC(B27)·······
·······························································································································RWTGRCMSCC(B27)······
·········································································································································SSRTRRETQL(B14)