HPV16 E6

Accession: H002099

Uniprot: G9HQE8

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MHQKRTAMFQ PQERPRKLP LCTELQTTI NIILECVYC QQLLRREVY FAFRDLCIV
         .         .         .         .         .         .
YRDGNPYAVC KCLKFYSKI EYRHYCYSL GTTLEQQYN PLCDLLIRC NCQKPLCPE
         .         .         .                              
EKQRHLDKKQ FHNIRGRWT RCMSCCRSS TRRETQL  

Epitope&Mutation

>H002099_E6
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHNIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
······AMFQDPQER(A3)···········································································································································
······AMFQDPQER(A11)··········································································································································
········FQDPQERPRK(A11)·······································································································································
············QERPRKLPQL(B7)····································································································································
·················KLPQLCTEL(A*0201)····························································································································
·················KLPQLCTEL(A2)································································································································
································IILECVYCK(A11)················································································································
····································CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
········································KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
················································VYDFAFRDL(A*2402)·····························································································
···················································FAFRDLCIVY(B35)····························································································
···················································FAFRDLCIVY(B57)····························································································
···················································FAFRDLCIV(A*0201)··························································································
···················································FAFRDLCIV(A2)······························································································
······················································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
··························································IVYRDGNPY(A3)·······················································································
··························································IVYRDGNPY(A11)······················································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·································································PYAVCDKCL(A*2402)············································································
···································································AVCDKCLK(A11)··············································································
······································································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
······································································DKCLKFYS(A24)···········································································
········································································CLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCD(DP)·················································
··········································································KFYSKISEY(A24)······································································
··········································································KFYSKISEY(B62)······································································
············································································YSKISEYRHY(A1)····································································
···············································································ISEYRHYCY(B18)·································································
···············································································ISEYRHYCY(A1)··································································
···············································································ISEYRHYCY(A11)·································································
·················································································EYRHYCYSL(A*2402)····························································
······················································································CYSLYGTTL(A*2402)·······················································
······················································································CYSLYGTTL(A24)··························································
··························································································YGTTLEQQYN(A24)·····················································
··························································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
···························································································GTTLEQQYNK(A11)····················································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
····························································································TTLEQQYNK(A3)·····················································
····························································································TTLEQQYNK(A11)····················································
·································································································QYNKPLCDLL(A24)··············································
·································································································QYNKPLCDL(A*2402)············································
····································································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·····································································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
·········································································································LLIRCINCQK(A11)······································
·········································································································LLIRCINCQK(A3)·······································
·········································································································LLIRCINCQK(A11)······································
························································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
························································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
························································································································EKQRHLDKKQRFHNI(DR)···················
····························································································································HLDKKQRFH(A3)·····················
······························································································································DKKQRFHNIRGRWTG(DRB1*01)········
································································································································KQRFHNIRGR(DR*07)·············
··································································································································RFHNIRGRW(A24)··············
····································································································································HNIRGRWTGR(A*6801)········
········································································································································GRWTGRCMSC(B27)·······
·········································································································································RWTGRCMSCC(B27)······
···················································································································································SSRTRRETQL(B14)