HPV16 E7

Accession: H002056

Uniprot: Q8QRD4

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLDLQPETT LYCYEQLSD SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
CDSTLWLCVQ THVDIRTLE LLMGTLGIV PICSQKP  

Epitope&Mutation

>H002056_E7
MHGDTPTLHEYMLDLQPETTDLYCYEQLSDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLWLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP
MHGDTPTLHEYM(DR4 or DR15)·········································································
MHGDTPTLHEYMLDL(A2)···············································································
·HGDTPTLHEY(A1)···················································································
····TPTLHEYMLDLQPE(MHC II)········································································
····TPTLHEYMLDLQPET(A2)···········································································
······TLHEYMLDL(A*0201)···········································································
······TLHEYMLDL(B48)··············································································
······TLHEYMLDL(B8)···············································································
··········YMLDLQPET(A*0201)·······································································
··········YMLDLQPETT(A*0201)······································································
··········YMLDLQPETT(A*0201)······································································
···········MLDLQPETT(A*0201)······································································
···········MLDLQPETT(A2)··········································································
·················ETTDLYCYE(A1)····································································
··································EDEIDGPAGQAEPDRA(DQ2)···········································
···········································QAEPDRAHY(B18)·········································
···············································DRAHYNIVTFCCKCD(DR15)······························
················································RAHYNIVTF(A*0201)·································
················································RAHYNIVTF(A24)····································
·················································AHYNIVTFCCKCD(DR15)······························
·························································CCKCDSTL(B8)·····························
·································································LCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP(MHC II)
··································································LCVQSTHVDI(A*2402)··············
····································································VQSTHVDIRTLEDLLMGT(MHC II)····
······································································STHVDIRTLEDLLMG(DQB1*0201)··
········································································HVDIRTLED(A2)·············
···········································································IRTLEDLLMGT(DR12)······
··············································································LEDLLMGTL(B60)······
···············································································DLLMGTLGIVCPICSQKP(DRB1*0901)
·················································································LLMGTLGIV(A*0201)
··················································································LMGTLGIVCPI(A*2402)
····················································································GTLGIVCPI(A*0201)
····················································································GTLGIVCPI(A2)·
·····················································································TLGIVCPI(A*0201)
·····················································································TLGIVCPIC(A*0201)
·····················································································TLGIVCPIC(A2)
·······················································································GIVCPICSQK(A11)
·······················································································GIVCPICSQK(A11)