HPV16 E2

Accession: H002055

Uniprot: B1A8X5

Protein: E2

Organism: Human papillomavirus type 16

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Sequence&Mutation

         .         .         .         .         .         .
METLCQRLNV QDKILTHYE DSTDLRDHI YWKHMRLEC IYYKAREMG KHINHQVVP
         .         .         .         .         .         .
TLAVSKNKAL AIELQLTLE IYNSQYSNE WTLQDVSLE YLTAPTGCI KHGYTVEVQ
         .         .         .         .         .         .
FDGDICNTMH TNWTHIYIC EASVTVVEG VDYYGLYYV EGIRTYFVQ KDDAEKYSK
         .         .         .         .         .         .
NKVWEVHAGG VILCPTSVF SNEVSPPEI RQHLANHSA THTKAVALG EETQTTIQR
         .         .         .         .         .         .
PRSEPDTGNP HTTKLLHRD VDSAPILTA NSSHKGRIN NSNTTPIVH KGDANTLKC
         .         .         .         .         .         .
LRYRFKKHCK YTAVSSTWH TGHNVKHKS IVTLTYDSE QRDQFLSQV IPKTITVST
                                                            
GFMSI     

Epitope&Mutation

>H002055_E2
METLCQRLNVCQDKILTHYENDSTDLRDHIDYWKHMRLECAIYYKAREMGFKHINHQVVPTLAVSKNKALQAIELQLTLETIYNSQYSNEKWTLQDVSLEVYLTAPTGCIKKHGYTVEVQFDGDICNTMHYTNWTHIYICEEASVTVVEGQVDYYGLYYVHEGIRTYFVQFKDDAEKYSKNKVWEVHAGGQVILCPTSVFSSNEVSPPEIIRQHLANHSAATHTKAVALGTEETQTTIQRPRSEPDTGNPCHTTKLLHRDSVDSAPILTAFNSSHKGRINCNSNTTPIVHLKGDANTLKCLRYRFKKHCKLYTAVSSTWHWTGHNVKHKSAIVTLTYDSEWQRDQFLSQVKIPKTITVSTGFMSI
····································································ALQAIELQL(A*0201)························································································································································································································································································
····························································································TLQDVSLEV(A*0201)································································································································································································································································
·········································································································································YICEEASVTV(A*0201)··················································································································································································································
··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR)·····························································
··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR1)····························································
··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR2)····························································
··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR3)····························································
······················································································································································································································································································································LYTAVSSTWHWTGHN(DQ6)···································
···························································································································································································································································································································SSTWHWTGHNVKHKS(DRB1*1502)························
···························································································································································································································································································································SSTWHWTGHNVKHKSAIVTLTYDSEWQRDQ(DR)················
···························································································································································································································································································································SSTWHWTGHNVKHKSAIVTLTYDSEWQRDQ(DR1)···············
···························································································································································································································································································································SSTWHWTGHNVKHKSAIVTLTYDSEWQRDQ(DR2)···············
···························································································································································································································································································································SSTWHWTGHNVKHKSAIVTLTYDSEWQRDQ(DR3)···············
·········································································································································································································································································································································AIVTLTYDSEWQRDQFLSQVKIPKTITVSTGFMSI(DR)
·········································································································································································································································································································································AIVTLTYDSEWQRDQFLSQVKIPKTITVSTGFMSI(DR1)
·········································································································································································································································································································································AIVTLTYDSEWQRDQFLSQVKIPKTITVSTGFMSI(DR2)
·········································································································································································································································································································································AIVTLTYDSEWQRDQFLSQVKIPKTITVSTGFMSI(DR3)
·········································································································································································································································································································································AIVTLTYDSEWQRDQFLSQVKIPKTITVSTGFMSI(DR4)
·························································································································································································································································································································································FLSQVKIPKT(DR15)····
·····························································································································································································································································································································································KIPKTITVSTGFMSI(DR1)