HPV16 E6

Accession: H002053

Uniprot: A4L2Z6

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MHQNRTAMFE PQERPRKLP LCTELQTTI DIILECVYC QQLLRREVY FAFRDLCIV
         .         .         .         .         .         .
YRDGNPYAVC KCLKFYCKI EYRHYCYSL GTTLEQQYN PLCDLLIRC NCQKPLCPE
         .         .                                        
EKQRHLDKKQ FHNIRGRWT RCMSC   

Epitope&Mutation

>H002053_E6
MHQNRTAMFEDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYCKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSC
··········DPQERPRKLPQLCTELQTTIHD(DP*17)···········································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*1401)·········································································································
············QERPRKLPQL(B7)························································································································
·················KLPQLCTEL(A*0201)················································································································
·················KLPQLCTEL(A2)····················································································································
························ELQTTIHDIILECVY(A2)·······································································································
·························LQTTIHDII(A*0201)········································································································
····························TIHDIILECV(A*0201)····································································································
····························TIHDIILEC(B*4801)·····································································································
······························HDIILECV(B*4002)····································································································
································IILECVYCK(A11)····································································································
····································CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·····································································
········································KQQLLRREVYDFAFRDLCIVYR(DP)················································································
················································VYDFAFRDL(A*2402)·················································································
···················································FAFRDLCIVY(B35)················································································
···················································FAFRDLCIVY(B57)················································································
···················································FAFRDLCIV(A*0201)··············································································
···················································FAFRDLCIV(A2)··················································································
··························································IVYRDGNPY(A3)···········································································
··························································IVYRDGNPY(A11)··········································································
·································································PYAVCDKCL(A*2402)································································
···································································AVCDKCLK(A11)··································································
···············································································ISEYRHYCY(B18)·····················································
···············································································ISEYRHYCY(A1)······················································
···············································································ISEYRHYCY(A11)·····················································
·················································································EYRHYCYSL(A*2402)················································
······················································································CYSLYGTTL(A*2402)···········································
······················································································CYSLYGTTL(A24)··············································
··························································································YGTTLEQQYN(A24)·········································
··························································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)···························
···························································································GTTLEQQYNK(A11)········································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·························
····························································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)······················
····························································································TTLEQQYNK(A3)·········································
····························································································TTLEQQYNK(A11)········································
·································································································QYNKPLCDLL(A24)··································
·································································································QYNKPLCDL(A*2402)································
····································································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·················
·····································································································PLCDLLIRCINCQKPLCPEEKQ(DQ)···················
·········································································································LLIRCINCQK(A11)··························
·········································································································LLIRCINCQK(A3)···························
·········································································································LLIRCINCQK(A11)··························
························································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)
························································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)
························································································································EKQRHLDKKQRFHNI(DR)·······
····························································································································HLDKKQRFH(A3)·········
······························································································································DKKQRFHNIRGRWTG(DRB1*01)
································································································································KQRFHNIRGR(DR*07)·
··································································································································RFHNIRGRW(A24)··
····································································································································HNIRGRWTGR(A*6801)
·······································································································································GRWTGRCMSC(B27)