HPV16 E6

Accession: H002021

Uniprot: A1YT19

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
AMFQDPQERP KLPQLCTEL TTIHDIILA VYCKQQLLR EVYDFAFRD CIVYRDGNP
         .         .         .         .         .         .
YAVCDKCLKF SKISEYRHY YSVYGTTLE QYNKPLCDL IRCINCQKP CPEEKQRHL
         .         .         .                              
DKKQRFHNIR RWTGRCMSC RSSRTRRET L  

Epitope&Mutation

>H002021_E6
AMFQDPQERPRKLPQLCTELQTTIHDIILACVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
AMFQDPQER(A3)···········································································································································
AMFQDPQER(A11)··········································································································································
··FQDPQERPRK(A11)·······································································································································
····DPQERPRKLPQLCTELQTTIHD(DP*17)·······················································································································
····DPQERPRKLPQLCTELQTTIHD(DP*1401)·····················································································································
······QERPRKLPQL(B7)····································································································································
···········KLPQLCTEL(A*0201)····························································································································
···········KLPQLCTEL(A2)································································································································
···················LQTTIHDII(A*0201)····················································································································
······························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
··································KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
··········································VYDFAFRDL(A*2402)·····························································································
·············································FAFRDLCIVY(B35)····························································································
·············································FAFRDLCIVY(B57)····························································································
·············································FAFRDLCIV(A*0201)··························································································
·············································FAFRDLCIV(A2)······························································································
················································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
····················································IVYRDGNPY(A3)·······················································································
····················································IVYRDGNPY(A11)······················································································
······················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
······················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
···························································PYAVCDKCL(A*2402)············································································
·····························································AVCDKCLK(A11)··············································································
································································DKCLKFYS(A24)···········································································
····································································KFYSKISEY(A24)······································································
····································································KFYSKISEY(B62)······································································
······································································YSKISEYRHY(A1)····································································
·········································································ISEYRHYCY(B18)·································································
·········································································ISEYRHYCY(A1)··································································
·········································································ISEYRHYCY(A11)·································································
··············································································HYCYSVYGTTLEQQY(DR)·······················································
····················································································YGTTLEQQYN(A24)·····················································
····················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·····················································································GTTLEQQYNK(A11)····················································
······················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
······················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
······················································································TTLEQQYNK(A3)·····················································
······················································································TTLEQQYNK(A11)····················································
···························································································QYNKPLCDLL(A24)··············································
···························································································QYNKPLCDL(A*2402)············································
······························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
···································································································LLIRCINCQK(A11)······································
···································································································LLIRCINCQK(A3)·······································
···································································································LLIRCINCQK(A11)······································
··················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
··················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
··················································································································EKQRHLDKKQRFHNI(DR)···················
······················································································································HLDKKQRFH(A3)·····················
························································································································DKKQRFHNIRGRWTG(DRB1*01)········
··························································································································KQRFHNIRGR(DR*07)·············
····························································································································RFHNIRGRW(A24)··············
······························································································································HNIRGRWTGR(A*6801)········
··································································································································GRWTGRCMSC(B27)·······
···································································································································RWTGRCMSCC(B27)······
·············································································································································SSRTRRETQL(B14)