HPV16 E5

Accession: H002012

Uniprot: J3XCH0

Protein: E5

Organism: Human papillomavirus type 16

Function

It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu

Sequence&Mutation

         .         .         .         .         .         .
MTNLDTASTT LACFLLCFC LLCVCLLIR LLLSVSTYT LILLVLVLW TAASAFRCF
         .         .                                        
LVYIVFVYIP FLIHTHARF IT   

Epitope&Mutation

>H002012_E5
MTNLDTASTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYTSLILLVLVLWITAASAFRCFLVYIVFVYIPLFLIHTHARFLIT
··············FLLCFCVLL(A*0201)····················································
····················VLLCVCLLI(A*0201)··············································