HPV16 E5

Accession: H002004

Uniprot: Q9WGD7

Protein: E5

Organism: Human papillomavirus type 16

Function

It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu

Sequence&Mutation

         .         .         .         .         .         .
MTNLDTASTT LACFLLCFC LLCVCLLIR LLLSVSTYT LILLVLLLW TAASAFRCF
         .         .                                        
IVYIIFVYIP FLIHTHARF IT   

Epitope&Mutation

>H002004_E5
MTNLDTASTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYTSLILLVLLLWITAASAFRCFIVYIIFVYIPLFLIHTHARFLIT
··············FLLCFCVLL(A*0201)····················································
····················VLLCVCLLI(A*0201)··············································
·············································VLLLWITAA(A*0201)·····················
······························································YIIFVYIPL(A*0201)····