HPV16 E6

Accession: H002000

Uniprot: Q919B6

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PRKLPQLCTE QTTIHDIIL CVYCKQQLL REVYDFAFR LCIVYRDGN YAVCDKCLK
         .         .         .         .         .         .
FYSKISEYRH CYSLYGTAL QQYNKPLCD LIRCINCQK LCPEEKQRH DKKQRFHNI
         .         .                                        
RGRWTGRCMS CRSSRTRRE QL   

Epitope&Mutation

>H002000_E6
PRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTALEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
··KLPQLCTEL(A*0201)····························································································································
··KLPQLCTEL(A2)································································································································
·········ELQTTIHDIILECVY(A2)···················································································································
··········LQTTIHDII(A*0201)····················································································································
·············TIHDIILECV(A*0201)················································································································
·············TIHDIILEC(B*4801)·················································································································
···············HDIILECV(B*4002)················································································································
·················IILECVYCK(A11)················································································································
·····················CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
·························KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
·································VYDFAFRDL(A*2402)·····························································································
····································FAFRDLCIVY(B35)····························································································
····································FAFRDLCIVY(B57)····························································································
····································FAFRDLCIV(A*0201)··························································································
····································FAFRDLCIV(A2)······························································································
·······································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
···········································IVYRDGNPY(A3)·······················································································
···········································IVYRDGNPY(A11)······················································································
·············································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
·············································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
··················································PYAVCDKCL(A*2402)············································································
····················································AVCDKCLK(A11)··············································································
·······················································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
·······················································DKCLKFYS(A24)···········································································
···························································KFYSKISEY(A24)······································································
···························································KFYSKISEY(B62)······································································
·····························································YSKISEYRHY(A1)····································································
································································ISEYRHYCY(B18)·································································
································································ISEYRHYCY(A1)··································································
································································ISEYRHYCY(A11)·································································
··································································EYRHYCYSL(A*2402)····························································
··················································································QYNKPLCDLL(A24)··············································
··················································································QYNKPLCDL(A*2402)············································
·····················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
······················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
··························································································LLIRCINCQK(A11)······································
··························································································LLIRCINCQK(A3)·······································
··························································································LLIRCINCQK(A11)······································
·········································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
·········································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
·········································································································EKQRHLDKKQRFHNI(DR)···················
·············································································································HLDKKQRFH(A3)·····················
···············································································································DKKQRFHNIRGRWTG(DRB1*01)········
·················································································································KQRFHNIRGR(DR*07)·············
···················································································································RFHNIRGRW(A24)··············
·····················································································································HNIRGRWTGR(A*6801)········
·························································································································GRWTGRCMSC(B27)·······
··························································································································RWTGRCMSCC(B27)······
····································································································································SSRTRRETQL(B14)