HPV16 E6

Accession: H001997

Uniprot: B7T167

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MHQKRTAMFQ PQERPRKLP LCTELQTTI DIILECVYC QQLLRREVY FAFRDLCIV
         .         .         .         .         .         .
YRDGNPYAVC KCLKFYSKI EYRYYCYSL GTTLEQQYN LLCDLLIRC NCQKPLCPE
         .         .         .                              
EKQRHLDKKQ FHNMRGRWT RCMSCCRSS TRRETQL  

Epitope&Mutation

>H001997_E6
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRYYCYSLYGTTLEQQYNKLLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNMRGRWTGRCMSCCRSSRTRRETQL
······AMFQDPQER(A3)···········································································································································
······AMFQDPQER(A11)··········································································································································
········FQDPQERPRK(A11)·······································································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*17)·······················································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*1401)·····················································································································
············QERPRKLPQL(B7)····································································································································
·················KLPQLCTEL(A*0201)····························································································································
·················KLPQLCTEL(A2)································································································································
························ELQTTIHDIILECVY(A2)···················································································································
·························LQTTIHDII(A*0201)····················································································································
····························TIHDIILECV(A*0201)················································································································
····························TIHDIILEC(B*4801)·················································································································
······························HDIILECV(B*4002)················································································································
································IILECVYCK(A11)················································································································
····································CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
········································KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
················································VYDFAFRDL(A*2402)·····························································································
···················································FAFRDLCIVY(B35)····························································································
···················································FAFRDLCIVY(B57)····························································································
···················································FAFRDLCIV(A*0201)··························································································
···················································FAFRDLCIV(A2)······························································································
··························································IVYRDGNPY(A3)·······················································································
··························································IVYRDGNPY(A11)······················································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·································································PYAVCDKCL(A*2402)············································································
···································································AVCDKCLK(A11)··············································································
······································································DKCLKFYS(A24)···········································································
··········································································KFYSKISEY(A24)······································································
··········································································KFYSKISEY(B62)······································································
······················································································CYSLYGTTL(A*2402)·······················································
······················································································CYSLYGTTL(A24)··························································
··························································································YGTTLEQQYN(A24)·····················································
···························································································GTTLEQQYNK(A11)····················································
····························································································TTLEQQYNK(A3)·····················································
····························································································TTLEQQYNK(A11)····················································
·········································································································LLIRCINCQK(A11)······································
·········································································································LLIRCINCQK(A3)·······································
·········································································································LLIRCINCQK(A11)······································
····························································································································HLDKKQRFH(A3)·····················
········································································································································GRWTGRCMSC(B27)·······
·········································································································································RWTGRCMSCC(B27)······
···················································································································································SSRTRRETQL(B14)