HPV16 E6

Accession: H001989

Uniprot: Q919B1

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
RHFMHQKRTA FQDPQERPR LPQLCTELQ TIHEIILEC HCKQQLLRR VYDFAFRDL
         .         .         .         .         .         .
CIVYRDGNPY VCDKCLKFY KISEYRHYC SLYGTTLEQ YNKPLCDLL RCINCQKPL
         .         .         .         .                    
CPEEKQRHLD KQRFHNIRG WTGRCMSCC SSRTRRETQ  

Epitope&Mutation

>H001989_E6
RHFMHQKRTAMFQDPQERPRKLPQLCTELQTTIHEIILECVHCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
·········AMFQDPQER(A3)···········································································································································
·········AMFQDPQER(A11)··········································································································································
···········FQDPQERPRK(A11)·······································································································································
···············QERPRKLPQL(B7)····································································································································
····················KLPQLCTEL(A*0201)····························································································································
····················KLPQLCTEL(A2)································································································································
···········································KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
···················································VYDFAFRDL(A*2402)·····························································································
······················································FAFRDLCIVY(B35)····························································································
······················································FAFRDLCIVY(B57)····························································································
······················································FAFRDLCIV(A*0201)··························································································
······················································FAFRDLCIV(A2)······························································································
·························································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
·····························································IVYRDGNPY(A3)·······················································································
·····························································IVYRDGNPY(A11)······················································································
·······························································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
·······························································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
····································································PYAVCDKCL(A*2402)············································································
······································································AVCDKCLK(A11)··············································································
·········································································DKCLKFYSKISEYRHYCYSLYG(DP)······························································
·········································································DKCLKFYS(A24)···········································································
···········································································CLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCD(DP)·················································
·············································································KFYSKISEY(A24)······································································
·············································································KFYSKISEY(B62)······································································
···············································································YSKISEYRHY(A1)····································································
··················································································ISEYRHYCY(B18)·································································
··················································································ISEYRHYCY(A1)··································································
··················································································ISEYRHYCY(A11)·································································
····················································································EYRHYCYSL(A*2402)····························································
·························································································CYSLYGTTL(A*2402)·······················································
·························································································CYSLYGTTL(A24)··························································
·····························································································YGTTLEQQYN(A24)·····················································
·····························································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
······························································································GTTLEQQYNK(A11)····················································
·······························································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
·······························································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
·······························································································TTLEQQYNK(A3)·····················································
·······························································································TTLEQQYNK(A11)····················································
····································································································QYNKPLCDLL(A24)··············································
····································································································QYNKPLCDL(A*2402)············································
·······································································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
········································································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
············································································································LLIRCINCQK(A11)······································
············································································································LLIRCINCQK(A3)·······································
············································································································LLIRCINCQK(A11)······································
···························································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
···························································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
···························································································································EKQRHLDKKQRFHNI(DR)···················
·······························································································································HLDKKQRFH(A3)·····················
·································································································································DKKQRFHNIRGRWTG(DRB1*01)········
···································································································································KQRFHNIRGR(DR*07)·············
·····································································································································RFHNIRGRW(A24)··············
·······································································································································HNIRGRWTGR(A*6801)········
···········································································································································GRWTGRCMSC(B27)·······
············································································································································RWTGRCMSCC(B27)······
······················································································································································SSRTRRETQL(B14)