HPV16 E7

Accession: H001914

Uniprot: A1YQD7

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLDLQPETT LYCYEQLSD SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .                                        
CDSTLRLCVR THVDIRTLE LLMGTLGIV   

Epitope&Mutation

>H001914_E7
MHGDTPTLHEYMLDLQPETTDLYCYEQLSDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVRSTHVDIRTLEDLLMGTLGIV
MHGDTPTLHEYM(DR4 or DR15)·································································
MHGDTPTLHEYMLDL(A2)·······································································
·HGDTPTLHEY(A1)···········································································
····TPTLHEYMLDLQPE(MHC II)································································
····TPTLHEYMLDLQPET(A2)···································································
······TLHEYMLDL(A*0201)···································································
······TLHEYMLDL(B48)······································································
······TLHEYMLDL(B8)·······································································
··········YMLDLQPET(A*0201)·······························································
··········YMLDLQPETT(A*0201)······························································
··········YMLDLQPETT(A*0201)······························································
···········MLDLQPETT(A*0201)······························································
···········MLDLQPETT(A2)··································································
·················ETTDLYCYE(A1)····························································
··································EDEIDGPAGQAEPDRA(DQ2)···································
···········································QAEPDRAHY(B18)·································
···············································DRAHYNIVTFCCKCD(DR15)······················
················································RAHYNIVTF(A*0201)·························
················································RAHYNIVTF(A24)····························
·················································AHYNIVTFCCKCD(DR15)······················
·························································CCKCDSTL(B8)·····················
·························································CCKCDSTLRLC(DR17)················
····························································CDSTLRLCV(A*2402)·············
······································································STHVDIRTLEDLLMG(DQB1*0201)
········································································HVDIRTLED(A2)·····
···········································································IRTLEDLLMGT(DR12)
··············································································LEDLLMGTL(B60)
················································································LLMGTLGIV(A*0201)