HPV16 E5

Accession: H001900

Uniprot: J3UER3

Protein: E5

Organism: Human papillomavirus type 16

Function

It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu

Sequence&Mutation

         .         .         .         .         .         .
MTNLDTASTT LACFLLCFC LLCVCLLIR LLLSVSTYA LILLVLVLW TAASAFRCF
         .         .                                        
IVYIVFVYIP FLIHTHARV IT   

Epitope&Mutation

>H001900_E5
MTNLDTASTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYASLILLVLVLWITAASAFRCFIVYIVFVYIPLFLIHTHARVLIT
··············FLLCFCVLL(A*0201)····················································
····················VLLCVCLLI(A*0201)··············································