HPV16 E6

Accession: H001898

Uniprot: E1A4A4

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MHQKRTAMFQ PQERPRKLP LCTELQTTI DIILECVYC QQLLRREVY FAFRDLCIV
         .         .         .         .         .         .
YRDGNPYAVC KCLKFYSKI EYRHYCYSV GTTLEQQYN PLCDLLIRC NCQKPLCPE
         .         .         .                              
EKQRHLDKKQ FHNIRGRWT RCMSCCRSS TRETQL  

Epitope&Mutation

>H001898_E6
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRETQL
······AMFQDPQER(A3)··········································································································································
······AMFQDPQER(A11)·········································································································································
········FQDPQERPRK(A11)······································································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*17)······················································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*1401)····················································································································
············QERPRKLPQL(B7)···································································································································
·················KLPQLCTEL(A*0201)···························································································································
·················KLPQLCTEL(A2)·······························································································································
························ELQTTIHDIILECVY(A2)··················································································································
·························LQTTIHDII(A*0201)···················································································································
····························TIHDIILECV(A*0201)···············································································································
····························TIHDIILEC(B*4801)················································································································
······························HDIILECV(B*4002)···············································································································
································IILECVYCK(A11)···············································································································
····································CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)················································································
········································KQQLLRREVYDFAFRDLCIVYR(DP)···························································································
················································VYDFAFRDL(A*2402)····························································································
···················································FAFRDLCIVY(B35)···························································································
···················································FAFRDLCIVY(B57)···························································································
···················································FAFRDLCIV(A*0201)·························································································
···················································FAFRDLCIV(A2)·····························································································
······················································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)···································································
··························································IVYRDGNPY(A3)······················································································
··························································IVYRDGNPY(A11)·····················································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*0101)··································································
····························································YRDGNPYAVCDKCLKFYSKISE(DP*1401)··································································
·································································PYAVCDKCL(A*2402)···········································································
···································································AVCDKCLK(A11)·············································································
······································································DKCLKFYS(A24)··········································································
··········································································KFYSKISEY(A24)·····································································
··········································································KFYSKISEY(B62)·····································································
············································································YSKISEYRHY(A1)···································································
···············································································ISEYRHYCY(B18)································································
···············································································ISEYRHYCY(A1)·································································
···············································································ISEYRHYCY(A11)································································
····················································································HYCYSVYGTTLEQQY(DR)······················································
··························································································YGTTLEQQYN(A24)····················································
··························································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)······································
···························································································GTTLEQQYNK(A11)···················································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DR15)····································
····························································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)·································
····························································································TTLEQQYNK(A3)····················································
····························································································TTLEQQYNK(A11)···················································
·································································································QYNKPLCDLL(A24)·············································
·································································································QYNKPLCDL(A*2402)···········································
····································································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)····························
·····································································································PLCDLLIRCINCQKPLCPEEKQ(DQ)······························
·········································································································LLIRCINCQK(A11)·····································
·········································································································LLIRCINCQK(A3)······································
·········································································································LLIRCINCQK(A11)·····································
························································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)······
························································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)········
························································································································EKQRHLDKKQRFHNI(DR)··················
····························································································································HLDKKQRFH(A3)····················
······························································································································DKKQRFHNIRGRWTG(DRB1*01)·······
································································································································KQRFHNIRGR(DR*07)············
··································································································································RFHNIRGRW(A24)·············
····································································································································HNIRGRWTGR(A*6801)·······
········································································································································GRWTGRCMSC(B27)······
·········································································································································RWTGRCMSCC(B27)·····