HPV16 E2

Accession: H001887

Uniprot: Q71C70

Protein: E2

Organism: Human papillomavirus type 16

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Sequence&Mutation

         .         .         .         .         .         .
METLCQRLNV QDKILTHYE DSTNLRDHI YWKHMRLEC IYYKAREMG KHINHQVVP
         .         .         .         .         .         .
TLAVSKNKAL AIELQLTLE IYNPQYSNE WTLQDVSLE YLTAPTGCI KHGYTVEVQ
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FDGDICNTMH TNWKHIYIC EASVTVVEG VDYYGLYYV EGIQTYFVQ KDDAEKYSK
         .         .         .         .         .         .
NKVWEVHAGG VILCPTSVF SNEVSSPET RQHLANHSA THTKAVALG KETQTTIQR
         .         .         .         .         .         .
PRSEPDTGDP HTTKLLHRD VDSTPILTA NSSHKGRIN NSNTTPIVH KGDANTLKC
         .         .         .         .         .         .
LRYRFKKHCK YTAVSSTWH TGHNVKHKS IVTLTYDSE QREQFLSQV IPKTITVST
                                                            
GFMSI     

Epitope&Mutation

>H001887_E2
METLCQRLNVCQDKILTHYENDSTNLRDHIDYWKHMRLECAIYYKAREMGFKHINHQVVPTLAVSKNKALQAIELQLTLETIYNPQYSNEKWTLQDVSLEVYLTAPTGCIKKHGYTVEVQFDGDICNTMHYTNWKHIYICEEASVTVVEGQVDYYGLYYVHEGIQTYFVQFKDDAEKYSKNKVWEVHAGGQVILCPTSVFSSNEVSSPETIRQHLANHSAATHTKAVALGTKETQTTIQRPRSEPDTGDPCHTTKLLHRDSVDSTPILTAFNSSHKGRINCNSNTTPIVHLKGDANTLKCLRYRFKKHCKLYTAVSSTWHWTGHNVKHKSAIVTLTYDSEWQREQFLSQVKIPKTITVSTGFMSI
····································································ALQAIELQL(A*0201)························································································································································································································································································
····························································································TLQDVSLEV(A*0201)································································································································································································································································
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··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR1)····························································
··············································································································································································································································································FNSSHKGRINCNSNTTPIVHLKGDANTLKC(DR2)····························································
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·····························································································································································································································································································································································KIPKTITVSTGFMSI(DR1)