HPV16 E6

Accession: H001880

Uniprot: C0KXK8

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPR LPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYRDGNPY
         .         .         .         .         .         .
AVCDKCLKFY KISEYRHYC SVYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD
         .                                                  
KKQRFHNIRG WTGRRMSC    

Epitope&Mutation

>H001880_E6
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRRMSC
·FQDPQERPRK(A11)···························································································································
···DPQERPRKLPQLCTELQTTIHD(DP*17)···········································································································
···DPQERPRKLPQLCTELQTTIHD(DP*1401)·········································································································
·····QERPRKLPQL(B7)························································································································
··········KLPQLCTEL(A*0201)················································································································
··········KLPQLCTEL(A2)····················································································································
·················ELQTTIHDIILECVY(A2)·······································································································
··················LQTTIHDII(A*0201)········································································································
·····················TIHDIILECV(A*0201)····································································································
·····················TIHDIILEC(B*4801)·····································································································
·······················HDIILECV(B*4002)····································································································
·························IILECVYCK(A11)····································································································
·····························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·····································································
·································KQQLLRREVYDFAFRDLCIVYR(DP)················································································
·········································VYDFAFRDL(A*2402)·················································································
············································FAFRDLCIVY(B35)················································································
············································FAFRDLCIVY(B57)················································································
············································FAFRDLCIV(A*0201)··············································································
············································FAFRDLCIV(A2)··················································································
···············································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)························································
···················································IVYRDGNPY(A3)···········································································
···················································IVYRDGNPY(A11)··········································································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)·······················································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)·······················································
··························································PYAVCDKCL(A*2402)································································
····························································AVCDKCLK(A11)··································································
·······························································DKCLKFYS(A24)·······························································
···································································KFYSKISEY(A24)··························································
···································································KFYSKISEY(B62)··························································
·····································································YSKISEYRHY(A1)························································
········································································ISEYRHYCY(B18)·····················································
········································································ISEYRHYCY(A1)······················································
········································································ISEYRHYCY(A11)·····················································
·············································································HYCYSVYGTTLEQQY(DR)···········································
···················································································YGTTLEQQYN(A24)·········································
···················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)···························
····················································································GTTLEQQYNK(A11)········································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·························
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)······················
·····················································································TTLEQQYNK(A3)·········································
·····················································································TTLEQQYNK(A11)········································
··························································································QYNKPLCDLL(A24)··································
··························································································QYNKPLCDL(A*2402)································
·····························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·················
······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)···················
··································································································LLIRCINCQK(A11)··························
··································································································LLIRCINCQK(A3)···························
··································································································LLIRCINCQK(A11)··························
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)
·················································································································EKQRHLDKKQRFHNI(DR)·······
·····················································································································HLDKKQRFH(A3)·········
·······················································································································DKKQRFHNIRGRWTG(DRB1*01)
·························································································································KQRFHNIRGR(DR*07)·
···························································································································RFHNIRGRW(A24)··
·····························································································································HNIRGRWTGR(A*6801)