HPV16 E6

Accession: H001864

Uniprot: M1KC87

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
LPQLCTELQT IHDIILECV CKQQLLRRE YDFAFRDLC VYRDGNPYA SDKCLKFYS
         .         .         .         .         .         .
KISEYRHYCY VYGTTLEQQ NKPLCDLLI CINCQKPLC EEKQRHLDK QRFHNIRGR
         .                                                  
WTGRCMSCCR SRT    

Epitope&Mutation

>H001864_E6
LPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVSDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRT
······ELQTTIHDIILECVY(A2)·············································································································
·······LQTTIHDII(A*0201)··············································································································
··········TIHDIILECV(A*0201)··········································································································
··········TIHDIILEC(B*4801)···········································································································
············HDIILECV(B*4002)··········································································································
··············IILECVYCK(A11)··········································································································
··················CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)···········································································
······················KQQLLRREVYDFAFRDLCIVYR(DP)······················································································
······························VYDFAFRDL(A*2402)·······················································································
·································FAFRDLCIVY(B35)······················································································
·································FAFRDLCIVY(B57)······················································································
·································FAFRDLCIV(A*0201)····················································································
·································FAFRDLCIV(A2)························································································
········································IVYRDGNPY(A3)·················································································
········································IVYRDGNPY(A11)················································································
····················································DKCLKFYS(A24)·····································································
························································KFYSKISEY(A24)································································
························································KFYSKISEY(B62)································································
··························································YSKISEYRHY(A1)······························································
·····························································ISEYRHYCY(B18)···························································
·····························································ISEYRHYCY(A1)····························································
·····························································ISEYRHYCY(A11)···························································
··································································HYCYSVYGTTLEQQY(DR)·················································
········································································YGTTLEQQYN(A24)···············································
········································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·································
·········································································GTTLEQQYNK(A11)··············································
··········································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·······························
··········································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)····························
··········································································TTLEQQYNK(A3)···············································
··········································································TTLEQQYNK(A11)··············································
···············································································QYNKPLCDLL(A24)········································
···············································································QYNKPLCDL(A*2402)······································
··················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·······················
···················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·························
·······················································································LLIRCINCQK(A11)································
·······················································································LLIRCINCQK(A3)·································
·······················································································LLIRCINCQK(A11)································
······································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·
······································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)···
······································································································EKQRHLDKKQRFHNI(DR)·············
··········································································································HLDKKQRFH(A3)···············
············································································································DKKQRFHNIRGRWTG(DRB1*01)··
··············································································································KQRFHNIRGR(DR*07)·······
················································································································RFHNIRGRW(A24)········
··················································································································HNIRGRWTGR(A*6801)··
······················································································································GRWTGRCMSC(B27)·
·······················································································································RWTGRCMSCC(B27)