HPV16 E7

Accession: H001860

Uniprot: K0FFC3

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLDLQPETT LYCYEQLSD SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
CDCTLRLCVQ THVDIRTLE LLMGTLGIV PICS  

Epitope&Mutation

>H001860_E7
MHGDTPTLHEYMLDLQPETTDLYCYEQLSDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDCTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICS
MHGDTPTLHEYM(DR4 or DR15)······································································
MHGDTPTLHEYMLDL(A2)············································································
·HGDTPTLHEY(A1)················································································
····TPTLHEYMLDLQPE(MHC II)·····································································
····TPTLHEYMLDLQPET(A2)········································································
······TLHEYMLDL(A*0201)········································································
······TLHEYMLDL(B48)···········································································
······TLHEYMLDL(B8)············································································
··········YMLDLQPET(A*0201)····································································
··········YMLDLQPETT(A*0201)···································································
··········YMLDLQPETT(A*0201)···································································
···········MLDLQPETT(A*0201)···································································
···········MLDLQPETT(A2)·······································································
·················ETTDLYCYE(A1)·································································
··································EDEIDGPAGQAEPDRA(DQ2)········································
···········································QAEPDRAHY(B18)······································
···············································DRAHYNIVTFCCKCD(DR15)···························
················································RAHYNIVTF(A*0201)······························
················································RAHYNIVTF(A24)·································
·················································AHYNIVTFCCKCD(DR15)···························
··································································LCVQSTHVDI(A*2402)···········
····································································VQSTHVDIRTLEDLLMGT(MHC II)·
······································································STHVDIRTLEDLLMG(DQB1*0201)
········································································HVDIRTLED(A2)··········
···········································································IRTLEDLLMGT(DR12)···
··············································································LEDLLMGTL(B60)···
·················································································LLMGTLGIV(A*0201)
··················································································LMGTLGIVCPI(A*2402)
····················································································GTLGIVCPI(A*0201)
····················································································GTLGIVCPI(A2)
·····················································································TLGIVCPI(A*0201)
·····················································································TLGIVCPIC(A*0201)
·····················································································TLGIVCPIC(A2)