HPV16 E7

Accession: H001854

Uniprot: C0KXQ5

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHE MLDVQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YNIVTFCCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLE LLMGTLGIV PICSQKP  

Epitope&Mutation

>H001854_E7
MHGDTPTLHEYMLDVQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP
MHGDTPTLHEYM(DR4 or DR15)·········································································
·HGDTPTLHEY(A1)···················································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)····················································
·················ETTDLYCYE(A1)····································································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)···················································
··································EDEIDGPAGQAEPDRA(DQ2)···········································
··········································GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIR(DR3)················
··········································GQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDI(DR3)·················
···········································QAEPDRAHY(B18)·········································
···············································DRAHYNIVTFCCKCD(DR15)······························
················································RAHYNIVTF(A*0201)·································
················································RAHYNIVTF(A24)····································
·················································AHYNIVTFCCKCD(DR15)······························
··················································HYNIVTFCCKCDSTLRLCVQST(DP*1901)·················
·························································CCKCDSTL(B8)·····························
·························································CCKCDSTLRLC(DR17)························
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·······
····························································CDSTLRLCV(A*2402)·····················
·····························································DSTLRLCVQSTHVD(DR4 od DR15)··········
·································································LCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP(MHC II)
··································································LCVQSTHVDI(A*2402)··············
····································································VQSTHVDIRTLEDLLMGT(MHC II)····
······································································STHVDIRTLEDLLMG(DQB1*0201)··
········································································HVDIRTLED(A2)·············
···········································································IRTLEDLLMGT(DR12)······
··············································································LEDLLMGTL(B60)······
···············································································DLLMGTLGIVCPICSQKP(DRB1*0901)
·················································································LLMGTLGIV(A*0201)
··················································································LMGTLGIVCPI(A*2402)
····················································································GTLGIVCPI(A*0201)
····················································································GTLGIVCPI(A2)·
·····················································································TLGIVCPI(A*0201)
·····················································································TLGIVCPIC(A*0201)
·····················································································TLGIVCPIC(A2)
·······················································································GIVCPICSQK(A11)
·······················································································GIVCPICSQK(A11)