HPV16 E6

Accession: H001810

Uniprot: K0F2Y1

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
DPQERPRKLP LCTELQTTI DIILECVYC QQLLRREVY FAFRDLCIV RDGNPYAVC
         .         .         .         .         .         .
DKCLKFYSKI EYRYYCYSL GTTLEQQYN PLCDLLIRC NCQKPLCPD KQRHLDKKQ
         .         .                                        
RFHNIRGRWT RCMSCCRSS TRRETQL   

Epitope&Mutation

>H001810_E6
DPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRYYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPDEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
DPQERPRKLPQLCTELQTTIHD(DP*17)·······················································································································
DPQERPRKLPQLCTELQTTIHD(DP*1401)·····················································································································
··QERPRKLPQL(B7)····································································································································
·······KLPQLCTEL(A*0201)····························································································································
·······KLPQLCTEL(A2)································································································································
··············ELQTTIHDIILECVY(A2)···················································································································
···············LQTTIHDII(A*0201)····················································································································
··················TIHDIILECV(A*0201)················································································································
··················TIHDIILEC(B*4801)·················································································································
····················HDIILECV(B*4002)················································································································
······················IILECVYCK(A11)················································································································
··························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
······························KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
······································VYDFAFRDL(A*2402)·····························································································
·········································FAFRDLCIVY(B35)····························································································
·········································FAFRDLCIVY(B57)····························································································
·········································FAFRDLCIV(A*0201)··························································································
·········································FAFRDLCIV(A2)······························································································
················································IVYRDGNPY(A3)·······················································································
················································IVYRDGNPY(A11)······················································································
··················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
··················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·······················································PYAVCDKCL(A*2402)············································································
·························································AVCDKCLK(A11)··············································································
····························································DKCLKFYS(A24)···········································································
································································KFYSKISEY(A24)······································································
································································KFYSKISEY(B62)······································································
············································································CYSLYGTTL(A*2402)·······················································
············································································CYSLYGTTL(A24)··························································
················································································YGTTLEQQYN(A24)·····················································
················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·················································································GTTLEQQYNK(A11)····················································
··················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··················································································TTLEQQYNK(A3)·····················································
··················································································TTLEQQYNK(A11)····················································
·······················································································QYNKPLCDLL(A24)··············································
·······················································································QYNKPLCDL(A*2402)············································
·······························································································LLIRCINCQK(A11)······································
·······························································································LLIRCINCQK(A3)·······································
·······························································································LLIRCINCQK(A11)······································
··············································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
··············································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
··············································································································EKQRHLDKKQRFHNI(DR)···················
··················································································································HLDKKQRFH(A3)·····················
····················································································································DKKQRFHNIRGRWTG(DRB1*01)········
······················································································································KQRFHNIRGR(DR*07)·············
························································································································RFHNIRGRW(A24)··············
··························································································································HNIRGRWTGR(A*6801)········
······························································································································GRWTGRCMSC(B27)·······
·······························································································································RWTGRCMSCC(B27)······
·········································································································································SSRTRRETQL(B14)